Endocrine Abstracts

Background: Headache often occurs as incapacitating symptom among the patients with acromegaly. GH involvement in the pathophysiologic mechanism and an analgesic effect of somatostatin analogues has been described, but the exact mechanism is not clear. Whether the pan somatostatine (sst)-receptor agonists are superior as concern the antinociceptive effect than the more selective ones is not evidenced.Case report: A 21-year old woman, diagnosed with acrom...

Introduction: Vertebroplasty is a commonly performed technique in the management of vertebral compression fractures. However, it is associated with some serious adverse effects. Most complications are related to the leakage of bone cement (polymethylmethacrylate) into the spinal canal or the perivertebral venous system.Case report: A 74-year-old lady was subjected to percutaneous verterbroplasty for osteoporotic compression fractures on T11, T12, L1 and ...

Introduction: GH deficiency in adulthood is associated with increased cardiovascular risk, which is attributed to unfavorable changes in body composition and in metabolic parameters.Aim: We evaluated haemodynamic, metabolic, inflammatory and coagulation indices that may contribute to the increased cardiovascular risk in GH deficient subjects.Methods: Twenty-four patients diagnosed with GH deficiency (13 male), with a mean (S...

Background: Duration of postoperative follow-up in patients with pheochromocytoma/paraganglioma (PPGL) is still not clearly specified. It is estimated that 5-year risk of a new events (metastatic/recurrent disease) after surgery is 27% in young patients, 25% in those with paraganglioma and around 10% in older patients and those with pheochromocytoma. Arterial aneurysms (AA) accompanying PPGL are described as complication/comorbidity that affects prognosis in these patients.</p...

Background: Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms with increasing incidence and unpredictable behavior. Whole-exome sequencing studies of metastatic PanNETs have found recurrent genomic alterations in DAXX and ATRX, which correlate with corresponding loss of protein expression. Loss of DAXX/ATRX in PanNETs is reported to be associated with several, adverse clinicopathologic features and poor patient disease-free survival (DFS). Howev...